A Handheld, Colorimetric Optoelectronic Dynamics Analyzer (CODA) for Measuring Total Ammonia of Biological Samples

July 9, 2018

Nai-Yuan LiuPinar Cay-DurgunTianmiao LaiMark SprowlsLeslie ThomasMary Laura LindErica Forzani

Early Access Note:
Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are peer-reviewed and edited but not paginated. Both these types of Early Access articles are fully citable from the moment they appear in IEEE Xplore.

Abstract:

A Handheld, Colorimetric Optoelectronic Dynamics Analyzer (CODA) for Measuring Total Ammonia of Biological Samples

This work introduces a wireless, solid-state, portable, and automated device capable of semi-continuously measuring the total ammonia (ammonia (NH3) and ammonium (NH4 + )) levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than current ammonia quantification techniques. Medical professionals typically estimate NH4+ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device’s operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only five seconds and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions.

READ FULL ARTICLE ON IEEE XPLORE

Login

New Here? Sign Up

Looking for increased exposure in the field of biomedical engineering? EMBS offers journals, conferences and a community for biomedical engineers. Membership includes PULSE Magazine.

Join EMBS