Early Access An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem cells (hPSC) derived cardiomyocytes (hPSC-CM) by multi-electrode array (MEA) system.
Early Access Chemical fixation is the slowest and often the most uncontrolled step in the multi-step process of preparing tissue for histopathology. In order to reduce the time from taking a core needle biopsy to making a diagnosis, a new approach is proposed that optically monitors the common formalin fixation process.
Early Access The correct evaluation of the healing process is important to define proper times of fixator dynamization and removal, avoiding refractures. Unfortunately, a quantitative healing assessment is not yet available in clinical practice.
Early Access Background and objective: Immobility of the lower extremity due to medical conditions such as stroke can lead to medical complications such as deep vein thrombosis or ankle contracture, and thereafter prolonged recovery process of the patients.
Cancer gene expression data is of great importance in cancer subtype diagnosis and drug discovery. Many computational methods have been proposed to classify subtypes using those data. However, most of the previous computational methods suffer from poor interpretability, experimental noises, and low diagnostic quality.
Accurate segmentation of cardiac bi-ventricle (CBV) from magnetic resonance (MR) images has a great significance to analyze and evaluate the function of cardiovascular system. However, the complex structure of CBV image makes fully automatic segmentation as a well-known challenge.
Early Access Recent work has shown that sharp spectral edges in acoustic stimuli might have advantageous effects in the treatment of tonal tinnitus. In the course of this study we evaluate the long-term effects of spectrally notched hearing aids on the subjective tinnitus distress.
Objective: To demonstrate the utility of rheoencephalography (REG) for measuring cerebral blood flow and fluid dynamics during different stages of sleep. Methods: Anteroposterior cranial electrical impedance was measured with concurrent polysomnography in a group of healthy subjects during sleep.
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