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Featured Articles

A Method to Standardize Quantification of Left Atrial Scar From Delayed-Enhancement MR Images

R. Karim, A. Arujuna, R.J. Housden, J. Gill, H. Cliffe, K. Matharu, J. Gill, C.A. Rindaldi, M. O'Neil, D. Rueckert, R. Razavi, T. Schaeffter, K. Rhode

Standardization of quantification for left-atrial scar will allow the selection of patients who are predicted to respond well to ablation procedures for cardiac arrhythmias. This could improve the success rate of such procedures and reduce recurrence of arrhythmias. An algorithm to standardize quantification is proposed…

Authors

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An Adaptive Home-Use Robotic Rehabilitation System for the Upper Body

A. Dowling, O. Barzilay, Y. Lombrozo, A. Wolf

The research objective was to create a home-use robotic rehabilitation system. Data was obtained in real-time from a Microsoft Kinect™ and a wireless surface EMG system. Subjects completed visual follow exercise tasks in a 3D visual environment. Data from two training exercises were used to generate a neural network, which was used to simulate the subject’s individual performance. A wearable arm robot prototype was built that was able to mimic changes in a subject’s elbow angle in real-time…

Authors

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A DowlingA Dowling
Dr. Dowling joined the mechanical engineering faculty at Technion – Israel Institute of Technology as a Post-Doctoral Research Fellow in the Biorobotics and Biomechanics Laboratory (BRML). Dr. Dowling’s research interests are in medical robotics, specifically wearable robotics and robotic rehabilitation.

O BarzilayO Barzilay
Mr. Barilay is currently a Ph.D. candidate in mechanical engineering at the Biorobotics and Biomechanics Laboratory (BRML) at the Technion. His fields of interest include biorobotics, computer vision, computational geometry and artificial intelligence.

Y LombrozoY Lombrozo
Mr. Lombrozo received his B.Sc degree in mechanical engineering from the Technion – Israel Institute of Technology in 2012.

A WolfA Wolf
Dr. Wolf is part of the faculty of mechanical engineering at the Technion – Israel Institute of Technology, where he founded a new research lab, the Biorobotics and Biomechanics Lab (BRML). The objective of the research in the BRML is to develop fundamental theories in bio-kinematics and biomechanics and to apply these theories to applications in medical robotics and biorobotics. Prof. Wolf is a co-inventor and co-founder of Medrobotics.



Development of a Compact Rectenna for Wireless Powering of a Head-mountable Deep Brain Stimulation Device

K. Hosain, A. Kouzani, S. Tye, O. Abulseoud, A. Amiet, A. Galehdar, A. Kaynak, M. Berk

Design of a rectangular spiral planar inverted-F antenna (PIFA) at 915 MHz for wireless power transmission applications is proposed. The antenna and the rectifying circuitry form a rectenna which can produce DC power from a distant radio frequency energy transmitter. The generated DC power is used to operate a low power deep brain stimulation pulse generator…

Authors

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K HosainK Hosain
Mr. Hosain is pursuing a Ph.D. at Deakin University, Victoria, Australia. His current research interests include development of devices, and antennas and their applications to biomedical engineering, particularly deep brain stimulation.

A KouzaniA Kouzani
Dr. Kouzani is an Associate professor with the School of Engineering, Deakin University. He has been involved in over $2 million research grants, and has published over 240 refereed papers. His current research interests include medical/biological microsystems, microfluidic lab-on-a-chip systems, bioinstrumentation, and biosensors and implants. He is the Leader of Deakin University’s BioMEMS Research Group.

S TyeS Tye
Dr. Tye is an Assistant Professor of psychiatry and psychology, where she directs the Translational Neuroscience Laboratory, with a focus on developing valid preclinical models of treatment resistant depression and bipolar disorder for investigation of disease and therapeutic mechanisms, utilizing deep brain stimulation.

O AbulseoudO Abulseoud
Dr. Abulseoud is an Assistant Professor of psychiatry with Mayo Medical School, with clinical practice in mood disorders and teaching activities in psychopharmacology. He is involved in basic, clinical, and translational research with a focus on studying the disease process and novel therapeutic strategies.

A AmietA Amiet
Dr. Amiet is currently the head of the Electromagnetic Signature Management Group in the Maritime Division of DSTO. His research interests include passive and active radar absorbing material development, and radar cross section reduction methods.

A GaledharA Galedhar
Dr. Galedhar worked at the Royal Melbourne Institute of Technology (RMIT) until 2012 investigating the electromagnetic behaviour of advanced fibre composites and conformal load bearing antenna structure (CLAS). His research interests are multi functional platforms, load bearing conformal Corbon fiber reinforced polymers (CFRP) antennas, small antennas and radio frequency identification (RFID) antennas.

A KaynakA Kaynak
Dr. Kaynak is an Associate Professor in mechanical engineering. Subjects he teaches include physics, statics, dynamics, stress analysis, fibre science, and materials science. His research interests are polymer coatings, functional textiles, and sensors. He is a regular reviewer for various international journals and a coinventor in a patent on conducting polymer coated wool.

M BerkM Berk
Dr. Berk is a NHMRC Senior Principal research Fellow, and is Alfred Deakin Chair of Psychiatry at Deakin University, where he heads the IMPACT Strategic Research Centre. His major interests are in the discovery and implementation of novel therapies, and risk factors and prevention of psychiatric disorders.

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Published Articles

Acoustic Analysis of Inhaler Sounds from Community-Dwelling Asthmatic Patients for Automatic Assessment of Adherence

M. Holmes, S. D'Arcy, R. Costello, R. Reilly

Inhalers are devices which deliver medication to the airways in the treatment of chronic respiratory diseases. When used correctly inhalers relieve and improve patients’ symptoms. However, adherence to inhaler medication has been demonstrated to be poor, leading to reduced clinical outcomes, wasted medication and higher healthcare costs…

Authors

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M HolmesM Holmes
Mr. Holmes has been a PhD researcher with the Trinity Centre for Bioengineering in Trinity College Dublin, Ireland since 2011. His research interests lie in the area of biomedical engineering, including acoustic signal processing, developing objective metrics for analysing inhaler therapy and treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

S D'ArcyS D’Arcy
Dr. D’Arcy is currently a Project Manager in the Trinity Centre for Bioengineering, working primarily on medical device commercialisation and clinical trial management. Her research has included the use of speech as a potential bio marker of early onset of cognitive decline.

R CostelloR Costello
Dr. Costello is currently a Consultant Physician in Respiratory Medicine at Beaumont Hospital, Dublin, Ireland and Associate Professor of Medicine at the Royal College of Surgeons in Ireland. He is involved in both the clinical and research aspects of asthma, rhinitis and sleep medicine.

R ReillyR Reilly
Dr. Reilly is currently President of the European Society of Engineering and Medicine (ESEM). His research focuses on clinical neural engineering based on high density electrophysiological and neuroimaging based analysis of sensory and cognitive processing, analysis of data acquired from implanted devices and also bioacoustics.

FingerSight: Fingertip Haptic Sensing of the Visual Environment

S. Horvath, J. Galeotti, B. Wu, R. Klatzky, M. Siegel, G. Stetten

We present a novel device mounted on the fingertip for acquiring and transmitting visual information through haptic channels. In contrast to previous systems in which the user interrogates an intermediate representation of visual information, such as a tactile display representing a camera generated image…

Authors

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S Horvath
Ms. Horvath is a doctoral candidate at the Robotics Institute at Carnegie Mellon University. Her research interests are in medical device design and medical image analysis, with a focus on computer vision and optical engineering.

J Galeotti
Dr. Galeotti is a Senior Project Scientist in Robotics and an Adjunct Assistant Professor in Biomedical Engineering at Carnegie Mellon University and Bioengineering at the University of Pittsburgh. His research interests are in both biomedical optics and biomedical image analysis and visualization, especially for intraoperative guidance.

B Wu
Dr. Wu is an Assistant Professor in Arizona State University’s College of Technology & Innovation. His research interests are in spatial perception/cognition, the visual and haptic control of action, and human factors issues in real, teleoperated, or simulated medical operations.

R Klatzky
Dr. Klatzky is Professor of Psychology and Human Computer Interaction at Carnegie Mellon University. Her research interests are in human perception and cognition, with special emphasis on spatial cognition and haptic perception.

M Siegel
Dr. Siegel is a faculty member in Robotics and an affiliated faculty member in Human Computer Interaction at Carnegie Mellon University. His research interests are in sensing, sensors, perception, and display systems in robotics contexts.

G Stetten
Dr. Stetten is Professor of Bioengineering  at the University of Pittsburgh and Research Professor at the CMU Robotics Institute. His research is in image guided intervention, haptics, and image analysis.

In Vivo Brain Magnetic Resonance Spectroscopy: A Measurement of Biomarker Sensitivity to Post-Processing Algorithms

D. Cocuzzo, A. Lin, P. Stanwell, C. Mountford, N. Keshava

Clinical translation of reported biomarkers requires reliable and consistent algorithms to derive biomarkers. However, the literature reports statistically significant differences between one dimensional MRS measurements from control groups and subjects with disease states but frequently provides little information on the algorithms and parameters used…

Authors

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D CocuzzoD Cocuzzo
Mr. Cocuzzo is a graduate student at the Department of Computer Science at Stanford University, focusing on large scale distributed systems, security, and data mining. Previously, he was an engineer at Draper Laboratory in Cambridge, MA. Dan earned his B.S. in electrical engineering at Northeastern University in Boston, MA.

A LinA Lin
Dr. Lin is currently an Instructor with the Department of Radiology at Harvard Medical School and Research Associate at Brigham and Women’s Hospital, Boston, MA. He is also a visiting research associate at the Center of MR Research at University of Illinois Chicago. Dr. Lin’s primary research interests are the clinical applications of magnetic resonance spectroscopy.

P StanwellP Stanwell
Mr. Stanwell is currently an Associate Professor in the Faculty of Health and Medicine at The University of Newcastle, Australia. His research interest centers on developing medical imaging techniques to address clinically relevant needs including ischemic stroke imaging, traumatic brain injury, sport-related concussion, and radiation oncology.

C MountfordC Mountford
Dr. Mountford is currently a Professor in Radiology at The University of Newcastle in Australia and full Professor of Radiology at the Harvard Medical School in the USA. She is the Director of the Centre for MR in Health in Newcastle and Director of the Centre for Clinical Spectroscopy at the Brigham and Women’s Hospital in Boston. Professor Mountford is a Fellow of the International Society of Magnetic Resonance in Medicine.

N KeshavaN Keshava
Dr. Keshava is currently a Senior Principal Informatics Scientist in the Research and Development Information organization at AstraZeneca Pharmaceuticals in Waltham, MA. His responsibilities include developing analytics for big data challenges across all areas of drug development. He has also been the principal investigator on a variety of research programs focusing on neuroimaging, psychology, and neurophysiology.

RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring

H. Huang, P. Zhao, P. Chen, Y. Ren, X. Liu, M. Ferrari, Y. Hu, D. Akinwande

This paper presents the concept of using a specifically designed RFID tag helix antenna as the sensing agent to wirelessly monitor the drug dosage inside a capsule or reservoir. Such a convenient and low cost sensing mechanism can potentially be applied in transdermal or implanted controllable drug delivery systems…

Authors

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H HuangH Huang
Mr. Huang is currently working towards a Ph.D. degree at the Department of Electrical and Computer Engineering, University of Texas at Austin, and is working as a research assistant at the Methodist Hospital Research Institute. His research interests include wireless medical telemetry and novel nano-electronic devices for healthcare applications.

P ZhaoP Zhao
Mr. Zhao is a Ph.D. candidate at the University of Texas at Austin. He obtained a B.S. degree in Electronic Engineering at Tsinghua University in 2013. His current research interests include biomedical instrumentation and high throughput screen enabled by microfluidic technology.

PY ChenPY Chen
Dr. Chen is a Research Scientist at Intellectual Venture Laboratories in Bellevue, Washington. He received his Ph.D. in Electrical and Computer Engineering from the University of Texas at Austin in 2013. His research interests include various topics in physical and wave electronics, including high frequency electronics, electromagnetism, active and passive antennas, metamaterials, plasmonics, nanophotonics, and vacuum/solid-state nanoelectronic devices.

Y RenY Ren
Dr. Ren is a professor and director of the Complex Engineered System Lab (CESL) at Tsinghua University. He holds 15 patents, and has authored or coauthored over 120 technical papers in Internet complexity, P2P network and wireless communication. His research interests include the complexity of the body area network, Internet information sharing, wireless extension of mobile terminals, architecture of IoT with the mobile gateways.

X LiuX Liu
Dr. Liu joined the Methodist Hospital Research Institute in 2010 to develop a nanoengineering core facility. His research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease and his current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

M FerrariM Ferrari
Mr. Ferrari is President and CEO of Houston Methodist Research Institute, where he holds the Ernest Cockrell Jr. Distinguished Endowed Chair. He is also the director of the Institute of Academic Medicine and executive vice president of Houston Methodist, and is president of The Alliance for NanoHealth in Houston.

Y HuY Hu
Dr. Hu is an assistant member of The Methodist Hospital Research Institute; he directs a nanomedicine research program focusing on the development of novel nanomaterials and nanodevices and their applications to biomarker detection.

D AkinwandeD Akinwande
Dr. Akinwande is currently an Assistant Professor with the University of Texas, Austin. He is a co-inventor of a high-frequency bondwire interconnect. He has been honored with several awards including the inaugural IEEE nano Geim and Novoselov Graphene Prize, the NSF CAREER award, the Army and DTRA Young Investigator awards, the 3M Nontenured Faculty Award, and others.

Novel System for Real-Time Integration of 3-D Echocardiography and Fluoroscopy for Image-Guided Cardiac Interventions: Preclinical Validation and Clinical Feasibility Evaluation

A.V. Arujuna, R.J. Housden, R.J., Y. Ma, R. Rajani, G. Gao, N. Nijhof, P. Cathier, R. Bullens, G. Gijsbers, V. Parish, S. Kapetanakis, J. Hancock, C.A. Rinaldi, M. Cooklin, J. Gill, M. Thomas, M.D. O'neill, R. Razavi, K.S. Rhode

Real-time imaging is required to guide minimally invasive catheter-based cardiac interventions. While transesophageal echocardiography allows for high-quality visualization of cardiac anatomy, X-ray fluoroscopy provides excellent visualization of devices. We have developed a novel image fusion system that allows real-time integration…

Authors

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AV ArujunaAV Arujuna
Mr. Arujuna was a Clinical Research Fellow with King’s College London, Department of Imaging
Sciences and Biomedical Engineering from 2009 to 2012. His current research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, advanced pacing, and advanced imaging.

RJ HousdenRJ Housden
Dr. Houseden is currently a Post-Doctoral Researcher with the Division of Imaging Sciences and Biomedical Engineering, King’s College London, working primarily on image guidance systems for minimally-invasive cardiac catheterization. His research interests include ultrasound imaging, image processing, and surgical guidance systems.

Y MaY Ma
Dr. Ma is currently a Senior Lecturer with Computer Science and Creative Technologies, University of the West of England. His research interests are computer graphics, mobile technology, and medical image processing in general.

S KapetanakisS Kapetanakis
Mr. Kapetanakis is a Consultant of heart failure and cardiac imaging with Guy’s and St. Thomas’ NHS Foundation Trust. As well as conducting regular heart failure clinics and specialist echocardiography sessions, he is the lead for cardio-oncology and maintains runs a dedicated muscular dystrophy clinic. He is the educational lead for core medical trainees in cardiology.

MD O'NeillMD O’Neill
Mr. O’Neill is a Consultant Cardiologist and Electrophysiologist with St. Thomas’ Hospital London, and Reader of clinical cardiac electrophysiology with King’s College London. His primary research interests are the development and use of advanced signal processing and imaging technologies to improve arrhythmia characterization and treatment in patients with heart rhythm disturbances.

R RazaviR Razavi
Dr. Razavi is the Director of the KCL Centre for Excellence in Medical Engineering funded by the Welcome Trust and Engineering and Physical Sciences Research Council. His current research interests include cardiovascular MRI and MR-guided cardiac catheterization.

KS RhodeKS Rhode
Mr. Rhode specializes in translation of novel technologies into the clinical environment via collaborative research programmes with leading clinical and industrial partners. His research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, computer simulation of minimally invasive procedures, and medical robotics.

Hardware Development and Locomotion Control Strategy for an Over-Ground Gait Trainer: NaTUre-Gaits

T.P. Luu, K.H. Low, X. Qu, H.B. Lim, K.H. Hoon

Therapist-assisted body weight supported (TABWS) gait rehabilitation was introduced two decades ago. The benefit of TABWS in functional recovery of walking in spinal cord injury and stroke patients has been demonstrated and reported. However, shortage of therapists, labor-intensiveness, and short duration of training…

Authors

See complete bios of the authors in the full version of this article.

TP LuuTP Luu
Mr. Luu is currently pursuing a Ph.D. degree with the School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore. His research interests are lower and upper limb motor control strategies, and robotic rehabilitation systems.

KH LowKH Low
Dr. Low is currently a Professor with the School of Mechanical and Aerospace Engineering, Nanyang
Technological University, Singapore. His teaching and research interests include robotics, vibrations, impacts, exoskeleton systems, mechatronics design, machines, and mechanisms.

X QuX Qu
Dr. Qu is currently an Assistant Professor with the School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore. His research interests are in the areas of occupational biomechanics, and industrial ergonomics.

HB LimHB Lim
Mr. Lim is currently a Mechanical Design Engineer with Singapore Polytechnic. His research interests are functional motor recovery and assisted rehabilitation devices.

KH HoonKH Hoon
Dr. Hoon is an Associate Professor with the School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore. His research interest has been primary in stress analysis of structures and components, biomechanical analysis, design and development of assistive and rehabilitative gait devices.

Scope Statement

We focus on innovative solutions to healthcare needs from biomedical engineering, clinical engineering, and medical communities that bridge the engineering and clinical worlds. JTEHM's unique scope is original work at the intersection of engineering and clinical translation.

The journal’s focus is interdisciplinary collaborations among researchers, healthcare providers, and industry. We publish results and best practices from these translational efforts and serve as a community hub for researchers, clinicians, and developers who are addressing challenges in technology development, commercialization, and deployment for better global healthcare. Our ultimate goal is to improve the practice of engineering in translational medicine and to serve as a focal point for the nascent community. Our interactive content includes video, lively commentary, blogs, and other features to engage our clinical and engineering communities.