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Experimental Procedure for Determination of the Dielectric Properties of Biological Samples in the 2-50 GHz Range

E. Odelstad, S. Raman, A. Rydberg, R. Augustine

The objective of this paper was to test and evaluate an experimental procedure for providing data on the complex permittivity of different cell lines in the 2–50-GHz range at room temperature, for the purpose of future dosimetric studies. The complex permittivity measurements were performed on cells suspended in culture medium using an open-ended coaxial probe…

Authors

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E OdelstadE Odelstad
Mr. Odelstad is currently pursuing the Ph.D. degree in space and plasma physics with Uppsala University and the Swedish Institute of Space Physics, Kiruna, Sweden. His current research interests include the evolution of the plasma environment around comets and spacecraft plasma interactions.

S RamanS Raman
Dr. Raman is currently a Post-Doctoral Researcher in Solid-State Electronics with the Angstrom Laboratory, Uppsala University, Uppsala, Sweden. His research interests include designing of planar antennas, planar microwave devices, bioelectromagnetics, and microwave material characterization.

A RydbergA Rydberg
Dr. Rydberg heads the Microwave Group with the Department of Engineering Science, Uppsala University. He has authored and co-authored more than 220 publications in the area of micro and millimeterwave antennas, sensors, solid-state components and circuits, and holds three patents in the areas.

R AugustineR Augustine
Dr. Augustine is a Researcher with Uppsala University, Uppsala, Sweden. He has authored and co-authored more than 35 publications, including journals and conferences. His current research interests include designing of wearable antennas, BMD sensors, dielectric characterization, bioelectromagnetism, noninvasive diagnostics, and biological healing effects of RF in in vitro and in vivo systems.



Controlling knee swing initiation and ankle plantarflexion with an active prosthesis on level and inclined surfaces at variable walking speeds

N. P. Fey, A. M. Simon, A. J. Young, L. J. Hargrove

Improving lower-limb prostheses is important to enhance the mobility of amputees. The purpose of this study was to introduce an impedance-based control strategy (consisting of four novel algorithms) for an active knee and ankle prosthesis and test its generalizability across multiple walking speeds, walking surfaces and users…

Authors

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N FeyN Fey
Dr. Fey is currently a Post-Doctoral Research Fellow with the Center for Bionic Medicine, Rehabilitation Institute of Chicago, Chicago, IL, USA. He also has an appointment with the Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago. His overall research interest is to identify how given task demands and lower-limb assistive devices contribute to human motor control and biomechanics.

A SimonA Simon
Dr. Simon is a Biomedical Engineering Manager in the Center for Bionic Medicine at the Rehabilitation Institute of Chicago, and a Research Assistant Professor in the Department of Physical Medicine and Rehabilitation at Northwestern University. Her research interests include overcoming clinical challenges associated with the application of advanced pattern recognition myoelectric control systems for both upper- and lower-limb amputees.

A YoungA Young
Mr. Young is currently working toward the Ph.D. degree at Northwestern University in the Center for Bionic Medicine at the Rehabilitation Institute of Chicago. His research interests include neural signal processing and pattern recognition using advanced machine learning techniques for control of myoelectric prosthesis for the upper and lower limb.

L HargroveL Hargrove
Dr. Hargrove is Director of the Neural Engineering for Prosthetics and Orthotics Laboratory at CBM. He is also a Research Assistant Professor in the Department of Physical Medicine and Rehabilitation at Northwestern University. His research interests include pattern recognition, biological signal processing and myoelectric control of powered prostheses.



High-Frequency Oscillations Recorded on the Scalp of Patients with Epilepsy Using Tripolar Concentric Ring Electrodes

W. Besio, I. Martinez-Juarez, O. Makeyev, J. Gaitanis, A. Blum, R. Fisher, A. Medvedev

Electroencephalography (EEG) is a noninvasive means for recording electrical activity of the brain. We have developed tripolar concentric ring electrodes (TCREs) and have shown that TCREs provide higher signal-to-noise ratios, higher spatial resolution, and less mutual information than conventional disc electrodes. This paper describes the results of a clinical study of patients with epilepsy to determine if high-frequency oscillations (HFOs) were present in EEG recorded with TCREs.

Authors

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W BesioW Besio
Dr. Besio is an Associate Professor in the Electrical, Computer, and Biomedical Engineering Department at the University of Rhode Island. His laboratory performs research to develop innovative biomedical instrumentation for diagnosis and therapies for enhancing the lives of persons with disease and disability.

I Martinez-JuarezI Martinez-Juarez
Dr. Martínez-Juárez is a Neurologist-Epileptologist and Head of the Epilepsy Clinic, National Institute of Neurology and Neurosurgery, Mexico, Professor of Clinical Epileptology Fellowship, National Autonomous University of Mexico (UNAM) and National Institute of Neurology and Neurosurgery, Mexico. Her research interests are in juvenile myoclonic epilepsy and genetics of epilepsy.

O MakeyevO Makeyev
Dr. Makeyev is with the Department of Electrical, Computer, and Biomedical Engineering at the University of Rhode Island, Kingston, RI. His broad research interests include development and application of computational intelligence and statistics based signal processing and pattern recognition methods to engineering problems with an emphasis on biomedical engineering.

J GaitanisJ Gaitanis
Dr. Gaitanis is an Associate Professor of Neurology and Pediatrics (clinical) at the Warren Alpert Medical School of Brown University and the Director of Pediatric Epilepsy at Hasbro Children’s Hospital. His research interests include brain malformations, pediatric epilepsy, and use of electroencephalography in the diagnosis of neurological conditions.

A BlumA Blum
Dr. Blum is an Associate Professor of Neurology at the Alpert Medical School of Brown University. His current research interests focus upon epilepsy co-morbidities, particularly psychiatric and cognitive concerns, epilepsy in older populations, and the pathophysiology of epileptic seizures including mechanisms germane to SUDEP, sudden unexplained death in epilepsy.

R FisherR Fisher
Dr. Fisher is is Maslah Saul MD Professor and Director of the Stanford Epilepsy Center. He received the Ambassador Award from the International League Against Epilepsy, the 2005 AES Service Award, and the 2006 Annual Clinical Research Award. He has served on the Board of the ILAE and as Editor-in-Chief of the Journal, Epilepsia. His research is on new devices to treat epilepsy.

A MedvedevA Medvedev
Dr. Medvedev is a neurophysiologist and computational neuroscientist. His expertise includes systems electrophysiology, high density EEG, source localization, near-infrared optical brain imaging, functional connectivity, signal analysis and neural network modeling. Dr. Medvedev’s research focuses on neural mechanisms of cognitive processes in healthy participants as well as patients with various neurological disorders.

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Published Articles

Near Real-time Computer Assisted Surgery for Brain Shift Correction using Biomechanical Models

K. Sun, T.S. Pheiffer, A.L. Simpson, J.A. Weis, R.C. Thompson, M.I. Miga

Brain deformation during surgery compromises the fidelity of image-guided tumor resection procedures.  This paper presents a comprehensive framework to intraoperatively account for volumetric brain deformations within image-guided surgery systems using only measurements of cortical surface ‘shift’…

Authors

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K SunK Sun
Dr. Sun became a Staff Engineer at Vanderbilt University from 2010-2013 and is now a Biomedical
Computation and Modeling Scientist at CFD Research Corporation, Huntsville, AL. She received her PhD in Bioengineering from Rice University in 2006.

T PheifferT Pheiffer
Mr. Pheiffer received his M.S. from Vanderbilt University in Biomedical Engineering in 2010. He is currently a Ph.D. Candidate in Biomedical Engineering at Vanderbilt University, and his research interests include image-guided surgery and ultrasound imaging.

A SimpsonA Simpson
Dr. Simpson recieved her PhD in Computer Science from Queen’s University in 2010. She joined the faculty at Vanderbilt University in November of 2009 and is currently a Research Assistant Professor in Biomedical Engineering. Her research interests include evaluation and validation methodologies for surgical navigation and the computation and visualization of measurement uncertainty in surgery.

J WeisJ Weis
Dr. Weis received his PhD in Biomedical Engineering from Vanderbilt University in 2011. He is currently a Postdoctoral Research Fellow at the Vanderbilt University Institute of Imaging Science and the Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN.

R ThompsonR Thompson
Dr. Thompson was recruited to Vanderbilt University’s Department on Neurological surgery in 2002. Dr. Thompson is currently the William F. Meacham Professor and Chairman of Neurosurgery, Director of Neurosurgical Oncology and Director of the Vanderbilt Brain Tumor Center.

M MigaM Miga
Dr. Miga is currently Professor of Biomedical Engineering, Radiology & Radiological Sciences, and Neurological Surgery. He also directs the Biomedical Modeling Laboratory and is co-founder of the Vanderbilt Initiative in Surgery and Engineering (VISE). The focus of his work is on the development of new paradigms in detection, diagnosis and treatment of disease through the integration of computational models into research and clinical practice.

Effective CPR Procedure with Real Time Evaluation and Feedback Using Smartphones

N.K. Gupta, V. Dantu, R. Dantu

Timely CPR can mean the difference between life and death. A trained person may not be available at emergency sites to give CPR. Normally, a 9-1-1 operator gives verbal instructions over the phone to a person giving CPR. In this paper, we discuss the use of smartphones to assist in administering CPR more efficiently and accurately. The two important CPR parameters are the frequency and depth of compressions…

Authors

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μ-Foil Polymer Electrode Array for Intracortical Neural Recordings

F. Ejserholm, P. Kohler, M. Granmo, J. Schouenborg, M. Bengtsson, L. Wallman

We have developed a multichannel electrode array, termed μ-foil, that comprises ultrathin and flexible electrodes protruding from a thin foil at fixed distances. This study is an early evaluation of technical aspects and performance of this electrode array in acute in vitro/in vivo experiments. The in vivo acute measurements showed…

Authors

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A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation with Jaw Closure in Normal Subjects Under Propofol Anesthesia

S. Ishizaka, S. Moromugi, M. Kobayashi, H. Kajihara, K. Koga, H. Sugahara, T. Ishimatsu, S. Kurata, J. Kirkness, K. Oi, T. Ayuse

Upper airway collapse is a dangerous problem in sedated patients who are undergoing surgery or imaging studies, and in people with sleep apnea. This paper presents the result of two clinical trials that examined the effect of a remote-controlled airbag device to control head, neck and jaw position and prevent airway collapse in patients who are sedated for surgery or diagnostic imaging, and for prevention of sleep apnea. The results of both studies demonstrate the promise of the device…

Authors

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Urine Flow Dynamics Through Prostatic Urethra With Tubular Organ Modeling Using Endoscopic Imagery

T. Ishii, Y. Kambara, T. Yamanishi, Y. Naya, T. Igarashi

Visualization of urine flow behavior through the prostatic urethra. A sequence of cystourethroscopic video images during the withdrawal maneuver was processed to generate a 3D model of the intraluminal shape of the urethra. Computation of urine flow dynamics in the urethra would unveil the critical lesions responsible for voiding dysfunction…

Authors

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T IshiiT Ishii
Mr. Ishii has been a Research Fellow of the Japan Society for the Promotion of Science since 2012. His research interests include image processing for endoscopic images, in particular, spatial recognition of body cavity for medical staffs and uid dynamics analysis in the lower urinary tract.

Y KambaraT Ishii
Mr. Kambara has received B.Sc. and M.Sc. degrees in engineering from Chiba University, Chiba, Japan, in 2011 and 2013, respectively. His research topics are shape modeling of the urinary tract and urine ow analysis for voiding dysfunction.

T YamanishiT Yamanishi
Prof. Yamanishi is a Professor of Urology at Dokkyo Medical University. He is also a Boarding Member of the Japanese Urological Association, Japanese Neurogenic Bladder Society, Japan Medical Association of Spinal Cord Lesion, and Japanese Association of Enuresis, and also a member of the International Continence Society, European Association of Urology, American Urological Association, International Spinal Cord Society, and International Urogynecological Association.

Y NayaY Naya
Dr. Naya is a top-ranked surgeon in Japan, particularly in the urological field. His research interests are laparoscopic surgery for the urogenital organs and endourology, in particular, establishment of focal therapy in the urological field.

T IgarashiT Igarashi
Dr. Igarashi is a Professor at the Research Center for Frontier Medical Engineering, since 2003. His research interests are endoscopic image processing and macroscopic ow dynamics in the body cavity, in particular, the novel surgical system carried out under water.

A Method to Standardize Quantification of Left Atrial Scar From Delayed-Enhancement MR Images

R. Karim, A. Arujuna, R.J. Housden, J. Gill, H. Cliffe, K. Matharu, J. Gill, C.A. Rindaldi, M. O'Neill, D. Rueckert, R. Razavi, T. Schaeffter, K. Rhode

Standardization of quantification for left-atrial scar will allow the selection of patients who are predicted to respond well to ablation procedures for cardiac arrhythmias. This could improve the success rate of such procedures and reduce recurrence of arrhythmias. An algorithm to standardize quantification is proposed…

Authors

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R KarimR Karim
Mr. Karim has been a Post-Doctoral Research Fellow with the King’s College London Medical Engineering Centre. since 2010. His current research interests include myocardial scar classication from MR, image-guided robotics, and left atrial surface parameterization.

A ArujunaA Arujuna
Mr. Arujuna was a Clinical Research Fellow with the Department of Imaging Sciences and Biomedical Engineering, King’s College London until 2012. He recieved an M.D. from the King’s College in 2013. His research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, advanced pacing, and advanced imaging.

R J HousdenR J Housden
Dr. Housden is currently a Post-Doctoral Researcher with the Division of Imaging Sciences and Biomedical Engineering, King’s College London, involved primarily in image guidance systems for minimally invasive cardiac catheterization. His research interests include ultrasound imaging, image processing, and surgical guidance systems.

H CliffeH Cliffe
Ms. Cliffe is in her penultimate year of reading medicine at King’s College, London, having received a Distinction for Pre-clinical Sciences. She is currently studying for a Diploma in Conict and Catastrophe Medicine at the Worshipful Society of Apothecaries of London, and is a Medical Cadet, sponsored through her studies by the Royal Air Force.

M O'NeillM O’Neill
Dr. O’Neill is a Clinical Lead of the King’s Health Partners Clinical Academic Group, Departmental Lead for Arrhythmias in Adult Congenital Heart Disease, and the Divisional Research Lead for electrophysiology. His primary research interests are the development and use of advanced signal processing and imaging technologies to improve arrhythmia characterization and treatment in patients with heart rhythm disturbances.

D RueckertD Rueckert
Dr. Rueckert is a Professor of Visual Information Processing and heads the Biomedical Image Analysis Group with the Department of Computing, Imperial College London. He is also an Associate Editor of the IEEE Transactions on Medical Imaging, an Editorial Board Member of Medical Image Analysis, Image and Vision Computing, and a Referee for a number of international medical imaging journals and conferences.

R RazaviR Razavi
Dr. Razavi is the Director of the KCL Centre for Excellence in Medical Engineering funded by the Welcome Trust and the Engineering and Physical Sciences Research Council. His current research interests include cardiovascular magnetic resonance imaging and MR-guided cardiac catheterization.

T SchaeffterT Schaeffter
Dr. Scaeffter’s current research interests include the investigation of new acquisition and reconstruction techniques for cardiovascular and quantitative MRI. In particular, he is involved in new techniques for MR-guided electrophysiology procedures and the quantitative assessment of ablation procedures. He has also pioneered a technique for Botulinum toxin injection for the treatment of overactive bladders.

K RhodeK Rhode
Dr. Rhode is a Senior Lecturer with the King’s College London. His research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, computer simulation of minimally invasive procedures, and medical robotics. He specializes in translation of novel technologies into the clinical environment via collaborative research programs with leading clinical and industrial partners.

Scope Statement

We focus on innovative solutions to healthcare needs from biomedical engineering, clinical engineering, and medical communities that bridge the engineering and clinical worlds. JTEHM's unique scope is original work at the intersection of engineering and clinical translation.

The journal’s focus is interdisciplinary collaborations among researchers, healthcare providers, and industry. We publish results and best practices from these translational efforts and serve as a community hub for researchers, clinicians, and developers who are addressing challenges in technology development, commercialization, and deployment for better global healthcare. Our ultimate goal is to improve the practice of engineering in translational medicine and to serve as a focal point for the nascent community. Our interactive content includes video, lively commentary, blogs, and other features to engage our clinical and engineering communities.