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Technical validation of ARTSENS – An image free device for evaluation of vascular stiffness

J. Joseph, R. Radhakrishnan, S. Kusmakar, A.S. Thrivikraman, M. Sivaprakasam

Vascular stiffness is an indicator of cardiovascular health, with carotid artery stiffness having established correlation to coronary heart disease and utility in cardiovascular diagnosis and screening. State of art equipment for stiffness evaluation are expensive, require expertise to operate and not amenable for field deployment…

Authors

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J JosephJ Joseph
Dr. Joseph is currently the Systems Architect at HTIC, IIT Madras, and deals with hardware projects involving sensors and instrumentation, system integration and medical device development. His main research interests apart from biomedical instrumentation include automated test and measurement, virtual instrumentation, and renewable energy resources.

R RadhakrishnanR Radhakrishnan
Dr. Radhakrishnan is a Consultant Interventional Radiologist and Preventive Cardiologist. He is the Director of Thambiran Heart and Vascular Institute, Annanagar, Chennai. He has been collaborating with HTIC over the past 2 years and has been jointly involved in multiple projects. He has more than 30 National and international Publications.

S KusmakarS Kusmakar
Mr. Kusmakar joined HTIC and worked as a clinical applications engineer during which time he anchored multiple clinical validation studies at HTIC. He is currently pursuing his doctoral studies at University of Melbourne, Australia.

A S ThrivikramanA S Thrivikraman
Ms. Thrivikraman received her undergraduate degree in Electronics and Instrumentation from College of Engineering, Trivandrum in 2011 and completed M.Tech in Instrument Technology from IIT Delhi in 2013. She is currently working in HTIC as Project Engineer.

M SivaprakasamM Sivaprakasam
Dr. Sivaprakasam is a faculty of Electrical Engineering at IIT Madras and Director of the Healthcare Technology Innovation Centre (HTIC), a R&D centre of IIT Madras. Since 2009, he has successfully built an ecosystem of technologists, clinicians and industry, culminating in setting up of Healthcare Technology Innovation Centre (HTIC) in 2011.



Integration of New Technology for Research in the Emergency Department: Feasibility of Deploying a Robotic Assessment Tool for Mild Traumatic Brain Injury Evaluation

V. Subbian, J. R. Ratcliff, J. M. Meunier, J. J. Korfhagen, F. R. Beyette, G. J. Shaw

This paper demonstrates the effective deployment of a robotic assessment tool for evaluation of mild Traumatic Brain Injury patients in a busy, resource-constrained, urban Emergency Department. Over 14 months, 1423 patients were screened and 42 of them completed both robot-assisted testing and follow-up assessment…

Authors

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V SubbianV Subbian
Mr. Subbian is currently an Instructor with the Department of Electrical Engineering and Computing Systems and a Research Coordinator with the Department of Emergency Medicine, University of Cincinnati. His research interests include biomedical devices and informatics, human-computer interaction, and engineering education.

J RatcliffJ Ratcliff
Mr. Ratcliff is currently an Assistant Professor of Emergency Medicine and Neurology with Emory University. His current research is focused on diagnosis and prognosis of traumatic brain injury and application of technology for acute care of neurologically-ill patients.

J MeunierJ Meunier
Mr. Meunier is currently a Clinical Research Coordinator with the Cincinnati VA Medical Center. His current research interests include post-traumatic stress disorder and cancer.

J KorfhagenJ Korfhagen
Mr. Korfhagen is currently a Post-Doctoral Fellow with the Department of Emergency Medicine, University of Cincinnati. His current research interests include development of novel techniques for improving neurocritical care.

F BeyetteF Beyette
Mr. Beyette is currently a Professor with the Department of Electrical Engineering and Computing Systems, University of Cincinnati. He is involved in research on design and implementation of mixed technology embedded systems with a particular focus on the development of novel point-of-care medical technologies with applications in many clinical and non-clinical health monitoring/assessment situations.

G ShawG Shaw
Dr. Shaw is currently an Associate Professor with the Department of Emergency Medicine, University of Cincinnati, and holds secondary appointments in biomedical engineering and neuroscience. His primary research interests include fundamental mechanisms of ultrasound enhanced thrombolysis, biomarkers for closed head injury, and thermal imaging for the clinical monitoring of cellulitis.



Automated Health Alerts Using In-Home Sensor Data for Embedded Health Assessment

M. Skubic, R.D. Guevara, M. Rantz

This paper proposes a model for early detection of health decline in seniors using personalized normals and continuous in-home monitoring with embedded sensors. Sensors embedded in senior housing apartments unobtrusively capture behavior and activity patterns. Changes in patterns are detected and analyzed as potential signs of changing health…

Authors

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M SkubicM Skubic
Dr. Skubic is currently a Professor with the Electrical and Computer Engineering Department, University of Missouri, with a joint appointment in Computer Science. Her current research interests include humanrobot interaction, spatial referencing interfaces, computational intelligence, sensor networks for eldercare, and preventative screening tools.

RD GuevaraRD Guevara
Mr. Guevara is currently a Software Engineer with Cerner Corporation, Kansas City, MO. His interests include computational intelligence, pattern recognition, eldercare technology, and wireless sensor networks.

M RantzM Rantz
Dr. Rantz is currently a Curators’ Professor with the Sinclair School of Nursing, University of Missouri, Columbia, where she holds the position of University Hospital Professor of Nursing, and has an appointment as a Professor with the Department of Family and Community Medicine, University of Missouri School of Medicine.

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Published Articles

Brain Cooling With Ventilation of Cold Air Over Respiratory Tract in Newborn Piglets: an Experimental and Numerical study

M.F. Bakhsheshi, H. Vafadar, E.E. Stewart, L. Keenliside, T.-Y. Lee

This paper investigates thermal effects of pulmonary cooling which was induced by cold air through an endotracheal tube via a ventilator on newborn piglets. We demonstrated that pulmonary cooling by cooling of inhalation gases immediately before they enter the trachea can slowly reduce brain and core body temperature of newborn piglets…

Authors

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Noninvasive Real-Time Automated Skin Lesion Analysis System for Melanoma Early Detection and Prevention

O. Abuzaghleh, B.D. Barkana, M. Faezipour

Melanoma spreads through metastasis, and therefore it has been proven to be very fatal. Statistical evidence has revealed that the majority of deaths resulting from skin cancer are as a result of melanoma. Further investigations have shown that the survival rates in patients depend on the stage of the cancer; early detection and intervention of melanoma implicates higher chances of cure…

Authors

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O AbuzaghlehO Abuzaghleh
Dr. Abuzaghleh is currently an Adjunct Faculty with the Computer Science and Engineering Department, University of Bridgeport. His research interests include image processing, virtual reality, humancomputer interaction, cloud computing, and distributed database management.

BD BarkanaBD Barkana
Dr. Barkana is currently an Associate Professor with the Electrical Engineering Department, University of Bridgeport, CT. She is also the Director of the Signal Processing Research Group Laboratory with the Electrical Engineering Program, University of Bridgeport.

M FaezipourM Faezipour
Dr. Faezipour is an Assistant Professor with the Computer Science and Engineering Department and the Biomedical Engineering Department, University of Bridgeport, CT, and is the Director of the Digital/Biomedical Embedded Systems and Technology Laboratory. Her research interests include biomedical signal processing and behavior analysis techniques, high-speed packet processing architectures, and digital/embedded systems.

Automatic Real-time Embedded QRS Complex Detection for a Novel Patch-Type Electrocardiogram Recorder

D.B. Saadi, G. Tanev, M. Flintrup, A. Osmanagic, K. Egstrup, K. Hoppe, P. Jennum, J.L. Jeppesen, H.K. Iversen, H.B.D. Sorensen

Cardiovascular diseases are projected to remain the single leading cause of death globally. Timely diagnosis and treatment of these diseases are crucial to prevent death and dangerous complications. One of the important tools in early diagnosis of arrhythmias is analysis of electrocardiograms (ECGs) obtained from ambulatory long-term recordings…

Authors

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DB SaadiDB Saadi
Ms. Saadi is currently pursuing a Ph.D. degree at the Department of Electrical Engineering, Technical University of Denmark. Her Ph.D. project is carried out in a close corporation with DELTA and Svendborg Hospital. Her research interests include automatic biomedical signal processing, heart arrhythmias, algorithm design, and clinical validations.

G TanevG Tanev
MR. Tanev received a M.Sc. Biomedical Engineering from the Technical University of Denmark and the University of Copenhagen, Denmark. His research interests include biomedical signal processing, heart rate variability, pulse transit time, portable medical technologies and real-time embedded systems.

M FlintrupM Flintrup
Mr. Flintrup is currently working as R&D Engineer and Software Team Lead in the ePatch Development Team in DELTA.

K EgstrupK Egstrup
Dr. Egstrup is a Chief physician at the Dept. of Medicine, Section of Cardiology, OUH Svendborg Hospital and a professor in Cardiology at University of Southern Denmark. He has received several awards for his research work.

K HoppeK Hoppe
Mr. Hoppe is currently working as Research Manager in the ePatch group at DELTA. His main interest is ePatch based medical device design.

JL JeppesenJL Jeppesen
Dr. Jeppesen is currently working as a consultant cardiologist and professor in the Department of Medicine, Glostrup Hospital, University of Copenhagen, Denmark.

HBD SorensenHBD Sorensen
Dr. Sorensen is currently Associate Professor and Head of the Biomedical Signal Processing research group at the Department of Electrical Engineering, Technical University of Denmark.

Current and Future Challenges in Point-of-Care Technologies: A Paradigm-Shift in Affordable Global Healthcare With Personalized and Preventive Medicine

A. Dhawan, W. Heetderks, M. Pavel, S. Acharya, M. Akay, A. Mairal, B. Wheeler, C. Dacso, T. Sunder, N. Lovell, M. Gerber, M. Shah, S.G. Senthilvel, M. Wang, B. Bhargava

This paper summarizes the panel discussion at the IEEE Engineering in Medicine and Biology Point-of-Care Healthcare Technology Conference (POCHT 2013) held in Bangalore India from Jan 16–18, 2013. Modern medicine has witnessed interdisciplinary technology innovations in healthcare with a continuous growth in life expectancy across the globe…

Authors

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A DhawanA Dhawan
Dr. Dhawan is currently a Distinguished Professor of Electrical and Computer Engineering and the Vice Provost of Research with the New Jersey Institute of Technology, where he serves as the Executive Director of the Interdisciplinary Design Studio, and is an Adjunct Professor of Radiology with the University of Medicine and Dentistry of New Jersey.

W HeetderksW Heetderks
Dr. Heetderks is the Director of Extramural Science Programs with the National Institute of Biomedical Imaging and Bioengineering, NIH. The extramural program supports approximately 800 research and training grants at universities and research centers throughout the United States in the fields of bioengineering and biomedical imaging.

M PavelM Pavel
Dr. Pavel currently holds a joint faculty appointment in the College of Computer & Information Science and Bouvé College of Health Sciences at Northeastern University. His current research is in the intersection of computational modeling of complex behaviors of biological systems, engineering, and cognitive science with a focus on information fusion, pattern recognition, augmented cognition, and the development of multimodal and perceptual humancomputer interfaces.

S AcharyaS Acharya
Dr. Acharya is an Assistant Research Professor with the Department of Biomedical Engineering, Johns Hopkins University. He serves as the Graduate Program Director of the Center for Bioengineering Innovation and Design with the Whiting School of Engineering. His research focuses on neural engineering.

M AkayM Akay
Dr. Akay is the Founding Chair of the Biomedical Engineering Department and the John S. Dunn Professor of Biomedical Engineering with the University of Houston. He has played a key role in promoting biomedical education in the world by writing and editing several books, special issues of prestigious journals including the PROCEEDINGS OF THE IEEE, and giving more than 100 keynote, plenary and invited talks.

A MairalA Mairal
Dr. Mairal is the Director of Global Exchange Programs with Stanford University. He has senior leadership roles with India and Singapore Biodesign programs. In these roles, he is responsible for developing an extensive network of partners from the industry, academia, regulatory bodies, and investors in Asia and the U.S. to foster these Asia-focused programs. Furthermore, he directs the NIH-funded Global Exchange Program.

B WheelerB Wheeler
Dr. Wheeler served as the 20142015 President of the IEEE Engineering in Medicine and Biology Society, the world’s largest, oldest, and most global bioengineering society. His research interests lie in the application of electrical engineering methodologies to neuroscience. His work inuenced the development of neural spike sorting technologies.

C DacsoC Dacso
Dr. Dacso is a Professor of Molecular and Cellular Biology and Medicine with the Baylor College of Medicine, a Hugh Roy and Lillie Cranz Cullen University Professor with the University of Houston, an Adjunct Professor of Electrical and Computer Engineering with Rice University, and a Consultant to the Biological Diagnostic Institute with Dublin City University.

T SunderT Sunder
Dr. Sunder is a Senior Consultant and Cardiothoracic and Transplant Surgeon at the Apollo Group of Hospitals, Chennai, India. He is also a Faculty Member of Minimally Invasive Thoracic Surgery at the Endo-Ethicon Institute, Chennai, Visiting Faculty, Department of Surgery, Annamalai University, Chidambaram, India; and Academic Coordinator, of the Department of Cardiothoracic Surgery, Apollo Hospitals, Chennai.

N LovellN Lovell
Dr. Lovell is one of the key researchers leading a research and development program to develop an Australian bionic eye. He is with the Graduate School of Biomedical Engineering, UNSW, where he is a Scientia Professor. His research work has covered areas of expertise ranging from cardiac modeling, telehealth technologies, biological signal processing, and visual prosthesis design.

M GerberM Gerber
Mr. Gerber is the Senior Research and Development Director of Medtronic, Mumbai, India. He is the Core Team Leader (Program General Manager) for complex neurostimulation systems and new therapy development. He is responsible for developing and commercializing new therapies and products, developing business cases and managing execution to ensure that therapy/product development meet goals for time-to-market, quality, development expense, and product cost.

M ShahM Shah
Mr. Shah is the Vice President and South Asia and Managing Director of India Medtronic. As the Vice President of South Asia, he is responsible for driving the company’s expansion and growth in the region, in addition to running the entire operations for Medtronic South Asia. He has over 28 years of experience in leadership, sales and marketing, and corporate planning positions in Healthcare, Specialty Chemicals, Telecommunications and Petrochemicals.

S G SenthilvelS G Senthilvel
Mr. Senthilvel is a Subject Matter Expert and an Industry Solutions Leader of Healthcare and Public Sector with IBM India. He is professionally qualified in the healthcare and life sciences domain with over 17 years of professional experience with
MNC Healthcare and IT organizations, as a SME, Principal Industry Consultant, Solution Architect, and Business Analyst.

M D WangM D Wang
Dr. Wang is a Tenured Associate Professor with The Wallace H. Coulter Joint Department of Biomedical Engineering, Georgia Tech and Emory University, and a Georgia Cancer Coalition Distinguished Cancer Scholar. She is also the Director of Bioinformatics and Biocomputing Core with the Emory-Georgia Tech Cancer Nanotechnology Center. Her bioinformatics software systems, such as caCORRECT and omniBiomarker have been certified by the National Cancer Informatics Program of NCI/NIH (a.k.a caBIG) as silver-level compatible.

B BhargavaB Bhargava
Dr. Bhargava is a Professor with the Department of Cardiology, Cardiothoracic Sciences Centre, and an Executive Director of the Stanford India Biodesign Centre and the All India Institute of Medical Sciences, New Delhi, India. He is one of the foremost leaders in biomedical innovation, public health, medical education, and medical research in India.

Engineering a High-Throughput 3D in vitro Glioblastoma Model

Y. Fan, N. G. Avci, D. T. Nguyen, A. Dragomir, Y. M. Akay, F. Xu, M. Akay

Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. The existing treatment for GBM, which involves a combination of resection, chemotherapy and radiotherapy, has a very limited success rate with a median survival rate of less than 1 year, mainly because of the failure of early detection and effective treatment. We present a novel 3D GBM cell culture model based on microwells that could mimic the in vivo environment and help to bypass the lack of suitable animal models for preclinical toxicity tests…

Authors

See complete bios of the authors in the full version of this article.

Y FanY Fan
Dr. Fan is currently a postdoc with University of Houston. His research interests are in 3D nano/micro-technologies, cutting-edge point of care methods, and translational research.

N G AvciN G Avci
Ms. Avci is currently a Ph.D. candidate in Department of Biomedical Engineering, University of Houston, Houston. Her research interest is to investigate the application of hydrogel microwells for in vitro 3D controlled-sized Glioblastoma (GBM) spheres formation and the treatment of GBM spheres with adenoviruses.

D T NguyenD T Nguyen
Mr. Nguyen is currently a PhD Candidate in Department of Biomedical Engineering, The University of Houston. His research interest is in the areas of drug delivery system, 3D cell culture and diagnostics.

A DragomirA Dragomir
Mr. Nguyen is currently a PhD Candidate in Department of Biomedical Engineering, The University of Houston. His research interest is in the areas of drug delivery system, 3D cell culture and diagnostics.

Y M AkayY M Akay
Dr. Akay is currently an Instructional and Research Assistant Professor at the Department of Biomedical Engineering, Cullen College of Engineering, University of Houston. Her current research interests include Molecular Neuroengineering, Neural Growth and Neurodegeneration.

F XuF Xu
Dr. Fu is a full professor at Xi’an Jiaotong University. His current research aims at advancing human health through academic excellence in education and research that integrates engineering, science biology and medicine with focus on Bio-thermo-mechanics, Engineering of Cell Microenvironment, and Point-of-Care Technologies.

M AkayM Akay
Dr. Akay is author/coauthor/editor of 14 books and giving more 50 keynote, plenary and invited talks at the international meetings including the first, second and third Latin-American Conference on Biomedical Engineering ’98, 01, 04. He has played a key role in promoting the biomedical education in the world by writing several prestigious books and editing the Biomedical Engineering Book Series.

An Optokinetic Nystagmus Detection Method for Use with Young Children

M. Sangi, B. Thompson, J. Turuwhenua

The detection of vision problems in early childhood can prevent neuro-developmental disorders such as amblyopia. However, accurate clinical assessment of visual function in young children is challenging. Optokinetic Nystagmus is a reflexive sawtooth motion of the eye that occurs in response to drifting stimuli that may allow for objective measurement of visual function in young children if appropriate child-friendly eye tracking techniques…

Authors

See complete bios of the authors in the full version of this article.

M SangiM Sangi
Mr. Sangi is studying toward a PhD at the Auckland Bioengineering Institute. Mehrdad’s doctoral research is focused on automated optokinetic nystagmus detection methods for use with young children.

B ThompsonB Thompson
Dr. Thompson has completed postdoctoral fellowships in the Department of Psychology, UCLA, USA and the Department of Ophthalmology, McGill University, Canada. He currently holds faculty positions at the University of Waterloo, Canada and the University of Auckland, New Zealand.

J TuruwhenuaJ Turuwhenua
Dr. Turuwhenua currently holds a joint appointment at the Auckland Bioengineering Institute and the Department of Optometry and Vision Science at the University of Auckland, New Zealand. Jason’s interests lie in the application of techniques from image processing and computer vision to eye related problems.

Scope Statement

We focus on innovative solutions to healthcare needs from biomedical engineering, clinical engineering, and medical communities that bridge the engineering and clinical worlds. JTEHM's unique scope is original work at the intersection of engineering and clinical translation.

The journal’s focus is interdisciplinary collaborations among researchers, healthcare providers, and industry. We publish results and best practices from these translational efforts and serve as a community hub for researchers, clinicians, and developers who are addressing challenges in technology development, commercialization, and deployment for better global healthcare. Our ultimate goal is to improve the practice of engineering in translational medicine and to serve as a focal point for the nascent community. Our interactive content includes video, lively commentary, blogs, and other features to engage our clinical and engineering communities.