Articles and Recent News
JTEHM Student Editor First Student Member of NASA’s GeneLab Steering Committee
JTEHM student editor Francesca Jarrett is the first student member of NASA GeneLab‘s Steering Committee. The mission of GeneLab is to expand scientists’ access to the research conducted in microgravity with experiments that explore the molecular response of terrestrial biology to a spaceflight environment.
Epilepsy Foundation Grant Opportunities
The following grants from the Epilepsy Foundation aim to advance the understanding of epilepsy that will lead to better treatment, more effective prevention, and ultimately to a cure. Information for funding opportunities in Fall 2016 and Spring 2017 is now available.
Spatial Heterogeneity Analysis in Evaluation of Cell Viability and Apoptosis for Colorectal Cancer Cells
In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3D in-vitro cell-based assays under the impact of anti-cancer agents. In 48-hour experiments using human colorectal cancer cell lines of HCT-116, SW-620 and SW-480, incubated cells are divided into control and drug administered groups, to be grown in matrigel and FOLFOX solution, respectively. Our 3D cell tracking and data acquisition system guiding an inverted microscope with a digital camera is utilized to capture bright field and fluorescent images of colorectal cancer cells at multiple time points.
A Smart-home System to Unobtrusively and Continuously Assess Loneliness in Older Adults
Loneliness is a common condition in older adults and is associated with increased morbidity and mortality, decreased sleep quality, and increased risk of cognitive decline. Assessing loneliness in older adults is challenging due to the negative desirability biases associated with being lonely. Thus, it is necessary to develop more objective techniques to assess loneliness in older adults.
More Than Just Accuracy: A Novel Method to Incorporate Multiple Test Attributes in Evaluating Diagnostic Tests Including Point of Care Tests
Current frameworks for evaluating diagnostic tests are constrained by a focus on diagnostic accuracy, and assume that all aspects of the testing process and test attributes are discrete and equally important. Determining the balance between the benefits and harms associated with new or existing tests has been overlooked. Yet, this is critically important information for stakeholders involved in developing, testing, and implementing tests.
Assessment of Carbon/Salt/Adhesive Electrodes for Surface Electromyography Measurements
We developed and tested new EMG electrodes that do not require hydrogel. The electrode is composed of carbon/salt/adhesive (CSA). We compared the performance of CSA to the standard Ag/AgCl electrodes subjected to various muscle contractions and relaxation movements. We found no significant differences in the signals’ amplitude, activation times and dynamics between two media during all muscle movements. Moreover, the CSA electrodes were found to be more resistant to noise and motion artifact contamination, and with lower spectral distortion than Ag/AgCl electrodes. CSA electrodes are potentially a suitable surrogate for Ag/AgCl electrodes for EMG with the added benefits of an infinite shelf-life and potentially lower cost.