Featured Articles

High-Frequency Oscillations Recorded on the Scalp of Patients with Epilepsy Using Tripolar Concentric Ring Electrodes

W. Besio, I. Martinez-Juarez, O. Makeyev, J. Gaitanis, A. Blum, R. Fisher, A. Medvedev

Electroencephalography (EEG) is a noninvasive means for recording electrical activity of the brain. We have developed tripolar concentric ring electrodes (TCREs) and have shown that TCREs provide higher signal-to-noise ratios, higher spatial resolution, and less mutual information than conventional disc electrodes. This paper describes the results of a clinical study of patients with epilepsy to determine if high-frequency oscillations (HFOs) were present in EEG recorded with TCREs.


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W BesioW Besio
Dr. Besio is an Associate Professor in the Electrical, Computer, and Biomedical Engineering Department at the University of Rhode Island. His laboratory performs research to develop innovative biomedical instrumentation for diagnosis and therapies for enhancing the lives of persons with disease and disability.

I Martinez-JuarezI Martinez-Juarez
Dr. Martínez-Juárez is a Neurologist-Epileptologist and Head of the Epilepsy Clinic, National Institute of Neurology and Neurosurgery, Mexico, Professor of Clinical Epileptology Fellowship, National Autonomous University of Mexico (UNAM) and National Institute of Neurology and Neurosurgery, Mexico. Her research interests are in juvenile myoclonic epilepsy and genetics of epilepsy.

O MakeyevO Makeyev
Dr. Makeyev is with the Department of Electrical, Computer, and Biomedical Engineering at the University of Rhode Island, Kingston, RI. His broad research interests include development and application of computational intelligence and statistics based signal processing and pattern recognition methods to engineering problems with an emphasis on biomedical engineering.

J GaitanisJ Gaitanis
Dr. Gaitanis is an Associate Professor of Neurology and Pediatrics (clinical) at the Warren Alpert Medical School of Brown University and the Director of Pediatric Epilepsy at Hasbro Children’s Hospital. His research interests include brain malformations, pediatric epilepsy, and use of electroencephalography in the diagnosis of neurological conditions.

A BlumA Blum
Dr. Blum is an Associate Professor of Neurology at the Alpert Medical School of Brown University. His current research interests focus upon epilepsy co-morbidities, particularly psychiatric and cognitive concerns, epilepsy in older populations, and the pathophysiology of epileptic seizures including mechanisms germane to SUDEP, sudden unexplained death in epilepsy.

R FisherR Fisher
Dr. Fisher is is Maslah Saul MD Professor and Director of the Stanford Epilepsy Center. He received the Ambassador Award from the International League Against Epilepsy, the 2005 AES Service Award, and the 2006 Annual Clinical Research Award. He has served on the Board of the ILAE and as Editor-in-Chief of the Journal, Epilepsia. His research is on new devices to treat epilepsy.

A MedvedevA Medvedev
Dr. Medvedev is a neurophysiologist and computational neuroscientist. His expertise includes systems electrophysiology, high density EEG, source localization, near-infrared optical brain imaging, functional connectivity, signal analysis and neural network modeling. Dr. Medvedev’s research focuses on neural mechanisms of cognitive processes in healthy participants as well as patients with various neurological disorders.

μ-Foil Polymer Electrode Array for Intracortical Neural Recordings

F. Ejserholm, P. Kohler, M. Granmo, J. Schouenborg, M. Bengtsson, L. Wallman

We have developed a multichannel electrode array, termed μ-foil, that comprises ultrathin and flexible electrodes protruding from a thin foil at fixed distances. This study is an early evaluation of technical aspects and performance of this electrode array in acute in vitro/in vivo experiments. The in vivo acute measurements showed…


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Effective CPR Procedure with Real Time Evaluation and Feedback Using Smartphones

N.K. Gupta, V. Dantu, R. Dantu

Timely CPR can mean the difference between life and death. A trained person may not be available at emergency sites to give CPR. Normally, a 9-1-1 operator gives verbal instructions over the phone to a person giving CPR. In this paper, we discuss the use of smartphones to assist in administering CPR more efficiently and accurately. The two important CPR parameters are the frequency and depth of compressions…


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Published Articles

Near Real-time Computer Assisted Surgery for Brain Shift Correction using Biomechanical Models

K. Sun, T.S. Pheiffer, A.L. Simpson, J.A. Weis, R.C. Thompson, M.I. Miga

Brain deformation during surgery compromises the fidelity of image-guided tumor resection procedures.  This paper presents a comprehensive framework to intraoperatively account for volumetric brain deformations within image-guided surgery systems using only measurements of cortical surface ‘shift’…


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K SunK Sun
Dr. Sun became a Staff Engineer at Vanderbilt University from 2010-2013 and is now a Biomedical
Computation and Modeling Scientist at CFD Research Corporation, Huntsville, AL. She received her PhD in Bioengineering from Rice University in 2006.

T PheifferT Pheiffer
Mr. Pheiffer received his M.S. from Vanderbilt University in Biomedical Engineering in 2010. He is currently a Ph.D. Candidate in Biomedical Engineering at Vanderbilt University, and his research interests include image-guided surgery and ultrasound imaging.

A SimpsonA Simpson
Dr. Simpson recieved her PhD in Computer Science from Queen’s University in 2010. She joined the faculty at Vanderbilt University in November of 2009 and is currently a Research Assistant Professor in Biomedical Engineering. Her research interests include evaluation and validation methodologies for surgical navigation and the computation and visualization of measurement uncertainty in surgery.

J WeisJ Weis
Dr. Weis received his PhD in Biomedical Engineering from Vanderbilt University in 2011. He is currently a Postdoctoral Research Fellow at the Vanderbilt University Institute of Imaging Science and the Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN.

R ThompsonR Thompson
Dr. Thompson was recruited to Vanderbilt University’s Department on Neurological surgery in 2002. Dr. Thompson is currently the William F. Meacham Professor and Chairman of Neurosurgery, Director of Neurosurgical Oncology and Director of the Vanderbilt Brain Tumor Center.

M MigaM Miga
Dr. Miga is currently Professor of Biomedical Engineering, Radiology & Radiological Sciences, and Neurological Surgery. He also directs the Biomedical Modeling Laboratory and is co-founder of the Vanderbilt Initiative in Surgery and Engineering (VISE). The focus of his work is on the development of new paradigms in detection, diagnosis and treatment of disease through the integration of computational models into research and clinical practice.

A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation with Jaw Closure in Normal Subjects Under Propofol Anesthesia

S. Ishizaka, S. Moromugi, M. Kobayashi, H. Kajihara, K. Koga, H. Sugahara, T. Ishimatsu, S. Kurata, J. Kirkness, K. Oi, T. Ayuse

Upper airway collapse is a dangerous problem in sedated patients who are undergoing surgery or imaging studies, and in people with sleep apnea. This paper presents the result of two clinical trials that examined the effect of a remote-controlled airbag device to control head, neck and jaw position and prevent airway collapse in patients who are sedated for surgery or diagnostic imaging, and for prevention of sleep apnea. The results of both studies demonstrate the promise of the device…


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Urine Flow Dynamics Through Prostatic Urethra With Tubular Organ Modeling Using Endoscopic Imagery

T. Ishii, Y. Kambara, T. Yamanishi, Y. Naya, T. Igarashi

Visualization of urine flow behavior through the prostatic urethra. A sequence of cystourethroscopic video images during the withdrawal maneuver was processed to generate a 3D model of the intraluminal shape of the urethra. Computation of urine flow dynamics in the urethra would unveil the critical lesions responsible for voiding dysfunction…


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T IshiiT Ishii
Mr. Ishii has been a Research Fellow of the Japan Society for the Promotion of Science since 2012. His research interests include image processing for endoscopic images, in particular, spatial recognition of body cavity for medical staffs and uid dynamics analysis in the lower urinary tract.

Y KambaraT Ishii
Mr. Kambara has received B.Sc. and M.Sc. degrees in engineering from Chiba University, Chiba, Japan, in 2011 and 2013, respectively. His research topics are shape modeling of the urinary tract and urine ow analysis for voiding dysfunction.

T YamanishiT Yamanishi
Prof. Yamanishi is a Professor of Urology at Dokkyo Medical University. He is also a Boarding Member of the Japanese Urological Association, Japanese Neurogenic Bladder Society, Japan Medical Association of Spinal Cord Lesion, and Japanese Association of Enuresis, and also a member of the International Continence Society, European Association of Urology, American Urological Association, International Spinal Cord Society, and International Urogynecological Association.

Y NayaY Naya
Dr. Naya is a top-ranked surgeon in Japan, particularly in the urological field. His research interests are laparoscopic surgery for the urogenital organs and endourology, in particular, establishment of focal therapy in the urological field.

T IgarashiT Igarashi
Dr. Igarashi is a Professor at the Research Center for Frontier Medical Engineering, since 2003. His research interests are endoscopic image processing and macroscopic ow dynamics in the body cavity, in particular, the novel surgical system carried out under water.

A Method to Standardize Quantification of Left Atrial Scar From Delayed-Enhancement MR Images

R. Karim, A. Arujuna, R.J. Housden, J. Gill, H. Cliffe, K. Matharu, J. Gill, C.A. Rindaldi, M. O'Neill, D. Rueckert, R. Razavi, T. Schaeffter, K. Rhode

Standardization of quantification for left-atrial scar will allow the selection of patients who are predicted to respond well to ablation procedures for cardiac arrhythmias. This could improve the success rate of such procedures and reduce recurrence of arrhythmias. An algorithm to standardize quantification is proposed…


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R KarimR Karim
Mr. Karim has been a Post-Doctoral Research Fellow with the King’s College London Medical Engineering Centre. since 2010. His current research interests include myocardial scar classication from MR, image-guided robotics, and left atrial surface parameterization.

A ArujunaA Arujuna
Mr. Arujuna was a Clinical Research Fellow with the Department of Imaging Sciences and Biomedical Engineering, King’s College London until 2012. He recieved an M.D. from the King’s College in 2013. His research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, advanced pacing, and advanced imaging.

R J HousdenR J Housden
Dr. Housden is currently a Post-Doctoral Researcher with the Division of Imaging Sciences and Biomedical Engineering, King’s College London, involved primarily in image guidance systems for minimally invasive cardiac catheterization. His research interests include ultrasound imaging, image processing, and surgical guidance systems.

H CliffeH Cliffe
Ms. Cliffe is in her penultimate year of reading medicine at King’s College, London, having received a Distinction for Pre-clinical Sciences. She is currently studying for a Diploma in Conict and Catastrophe Medicine at the Worshipful Society of Apothecaries of London, and is a Medical Cadet, sponsored through her studies by the Royal Air Force.

M O'NeillM O’Neill
Dr. O’Neill is a Clinical Lead of the King’s Health Partners Clinical Academic Group, Departmental Lead for Arrhythmias in Adult Congenital Heart Disease, and the Divisional Research Lead for electrophysiology. His primary research interests are the development and use of advanced signal processing and imaging technologies to improve arrhythmia characterization and treatment in patients with heart rhythm disturbances.

D RueckertD Rueckert
Dr. Rueckert is a Professor of Visual Information Processing and heads the Biomedical Image Analysis Group with the Department of Computing, Imperial College London. He is also an Associate Editor of the IEEE Transactions on Medical Imaging, an Editorial Board Member of Medical Image Analysis, Image and Vision Computing, and a Referee for a number of international medical imaging journals and conferences.

R RazaviR Razavi
Dr. Razavi is the Director of the KCL Centre for Excellence in Medical Engineering funded by the Welcome Trust and the Engineering and Physical Sciences Research Council. His current research interests include cardiovascular magnetic resonance imaging and MR-guided cardiac catheterization.

T SchaeffterT Schaeffter
Dr. Scaeffter’s current research interests include the investigation of new acquisition and reconstruction techniques for cardiovascular and quantitative MRI. In particular, he is involved in new techniques for MR-guided electrophysiology procedures and the quantitative assessment of ablation procedures. He has also pioneered a technique for Botulinum toxin injection for the treatment of overactive bladders.

K RhodeK Rhode
Dr. Rhode is a Senior Lecturer with the King’s College London. His research interests include image-guided cardiovascular interventions, cardiac electromechanical modeling, computer simulation of minimally invasive procedures, and medical robotics. He specializes in translation of novel technologies into the clinical environment via collaborative research programs with leading clinical and industrial partners.

An Adaptive Home-Use Robotic Rehabilitation System for the Upper Body

A. Dowling, O. Barzilay, Y. Lombrozo, A. Wolf

The research objective was to create a home-use robotic rehabilitation system. Data was obtained in real-time from a Microsoft Kinect™ and a wireless surface EMG system. Subjects completed visual follow exercise tasks in a 3D visual environment. Data from two training exercises were used to generate a neural network, which was used to simulate the subject’s individual performance. A wearable arm robot prototype was built that was able to mimic changes in a subject’s elbow angle in real-time…


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A DowlingA Dowling
Dr. Dowling joined the mechanical engineering faculty at Technion – Israel Institute of Technology as a Post-Doctoral Research Fellow in the Biorobotics and Biomechanics Laboratory (BRML). Dr. Dowling’s research interests are in medical robotics, specifically wearable robotics and robotic rehabilitation.

O BarzilayO Barzilay
Mr. Barilay is currently a Ph.D. candidate in mechanical engineering at the Biorobotics and Biomechanics Laboratory (BRML) at the Technion. His fields of interest include biorobotics, computer vision, computational geometry and artificial intelligence.

Y LombrozoY Lombrozo
Mr. Lombrozo received his B.Sc degree in mechanical engineering from the Technion – Israel Institute of Technology in 2012.

A WolfA Wolf
Dr. Wolf is part of the faculty of mechanical engineering at the Technion – Israel Institute of Technology, where he founded a new research lab, the Biorobotics and Biomechanics Lab (BRML). The objective of the research in the BRML is to develop fundamental theories in bio-kinematics and biomechanics and to apply these theories to applications in medical robotics and biorobotics. Prof. Wolf is a co-inventor and co-founder of Medrobotics.

Development of a Compact Rectenna for Wireless Powering of a Head-mountable Deep Brain Stimulation Device

K. Hosain, A. Kouzani, S. Tye, O. Abulseoud, A. Amiet, A. Galehdar, A. Kaynak, M. Berk

Design of a rectangular spiral planar inverted-F antenna (PIFA) at 915 MHz for wireless power transmission applications is proposed. The antenna and the rectifying circuitry form a rectenna which can produce DC power from a distant radio frequency energy transmitter. The generated DC power is used to operate a low power deep brain stimulation pulse generator…


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K HosainK Hosain
Mr. Hosain is pursuing a Ph.D. at Deakin University, Victoria, Australia. His current research interests include development of devices, and antennas and their applications to biomedical engineering, particularly deep brain stimulation.

A KouzaniA Kouzani
Dr. Kouzani is an Associate professor with the School of Engineering, Deakin University. He has been involved in over $2 million research grants, and has published over 240 refereed papers. His current research interests include medical/biological microsystems, microfluidic lab-on-a-chip systems, bioinstrumentation, and biosensors and implants. He is the Leader of Deakin University’s BioMEMS Research Group.

S TyeS Tye
Dr. Tye is an Assistant Professor of psychiatry and psychology, where she directs the Translational Neuroscience Laboratory, with a focus on developing valid preclinical models of treatment resistant depression and bipolar disorder for investigation of disease and therapeutic mechanisms, utilizing deep brain stimulation.

O AbulseoudO Abulseoud
Dr. Abulseoud is an Assistant Professor of psychiatry with Mayo Medical School, with clinical practice in mood disorders and teaching activities in psychopharmacology. He is involved in basic, clinical, and translational research with a focus on studying the disease process and novel therapeutic strategies.

A AmietA Amiet
Dr. Amiet is currently the head of the Electromagnetic Signature Management Group in the Maritime Division of DSTO. His research interests include passive and active radar absorbing material development, and radar cross section reduction methods.

A GaledharA Galedhar
Dr. Galedhar worked at the Royal Melbourne Institute of Technology (RMIT) until 2012 investigating the electromagnetic behaviour of advanced fibre composites and conformal load bearing antenna structure (CLAS). His research interests are multi functional platforms, load bearing conformal Corbon fiber reinforced polymers (CFRP) antennas, small antennas and radio frequency identification (RFID) antennas.

A KaynakA Kaynak
Dr. Kaynak is an Associate Professor in mechanical engineering. Subjects he teaches include physics, statics, dynamics, stress analysis, fibre science, and materials science. His research interests are polymer coatings, functional textiles, and sensors. He is a regular reviewer for various international journals and a coinventor in a patent on conducting polymer coated wool.

M BerkM Berk
Dr. Berk is a NHMRC Senior Principal research Fellow, and is Alfred Deakin Chair of Psychiatry at Deakin University, where he heads the IMPACT Strategic Research Centre. His major interests are in the discovery and implementation of novel therapies, and risk factors and prevention of psychiatric disorders.

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We focus on innovative solutions to healthcare needs from biomedical engineering, clinical engineering, and medical communities that bridge the engineering and clinical worlds. JTEHM's unique scope is original work at the intersection of engineering and clinical translation.

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